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Evaluation of the energetic contribution of an ionic network to beta-sheet stability
Kirsten S Lassila1, Deepshikha Datta, Stephen L Mayo
1Biochemistry Option, California Institute of Technology, MC 147-75, Pasadena, California 91125, USA.
Protein Science : a Publication of the Protein Society
|February 16, 2002
Abstract:
We have evaluated the interaction energy of a three-residue ionic network constructed on the beta-sheet surface of protein G using double mutant cycles. Although the two individual ion pairs were each stabilizing by 0.6 kcal/mol, the excess gain in stability for the triad was small (0.06 kcal/mol).