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Effect of tablet splitting on serum cholesterol concentrations
Megan C Duncan1, Sharon S Castle, Daniel S Streetman
1Veterans Affairs Medical Center, Huntington, WV, USA.
The Annals of Pharmacotherapy
|February 19, 2002
Summary
Splitting statin tablets like simvastatin and atorvastatin is safe and effective for managing cholesterol. This study found no significant increase in low-density lipoprotein (LDL) cholesterol or total cholesterol after patients switched to half-tablet dosing.
Area of Science:
- Cardiovascular Medicine
- Pharmacoeconomics
- Clinical Pharmacy
Background:
- Statin therapy is crucial for managing hyperlipidemia.
- Tablet splitting is a potential cost-saving strategy for patients.
Purpose of the Study:
- To assess the impact of tablet splitting on lipid profiles.
- Evaluate changes in low-density lipoprotein (LDL) cholesterol and total cholesterol.
Main Methods:
- Retrospective chart review of patients on simvastatin or atorvastatin.
- Analyzed lipid values before and after initiating half-tablet dosing.
- Ensured consistent dosage and adequate follow-up periods.
Main Results:
- No statistically significant increase in total cholesterol or LDL cholesterol was observed.
- A significant decrease in both total cholesterol (p=0.017) and LDL cholesterol (p=0.003) was noted post-splitting.
- Half-tablet dosing demonstrated comparable efficacy to whole-tablet dosing.
Conclusions:
- Tablet splitting of simvastatin and atorvastatin is an effective strategy.
- This practice supports quality patient care and potential cost savings.
- The program is continued at the Huntington VA Medical Center.