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Synthesis and pharmacological analysis of high affinity melatonin receptor ligands
Guo-Hua Chu1, Paula A Witt-Enderby, Marla Jones
1Department of Medicinal Chemistry and Pharmaceutics, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA, 15282, USA.
Chemical & Pharmaceutical Bulletin
|February 19, 2002
Abstract:
We report the synthesis and radioligand binding analysis of a series of naphthalenic melatonin receptor ligands, N-[2-(7-alkoxy-2-methoxy-1-naphthyl)ethyl]propionamide. This series of ligands exhibits subpicomolar binding affinity to both MT1 and MT2 melatonin receptors expressed in chinese hamster ovary (CHO) cells.