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Updated: Jan 20, 2026

Toxicity Screens in Human Retinal Organoids for Pharmaceutical Discovery
Published on: March 4, 2021
The use of retroviruses as pharmaceutical tools for target discovery and validation in the field of functional
J B Lorens1, C Sousa, M K Bennett
1Rigel, Inc., 240 East Grand Avenue, South San Francisco, CA 94080, USA. jblorens@rigel.com
Abstract:
Retrovirally mediated functional genomics enables identification of physiologically relevant cellular therapeutic targets. Unique properties of retroviruses make them ideal tools for the introduction of large and diverse libraries of potential genetic effectors to a variety of cell types. The identification and recovery of intracellular library elements responsible for altered disease responses establishes a direct basis for pharmaceutical development. Recent innovations in retroviral infection efficiency and expression control have broadened application of the methodology to include libraries of mutagenized cDNAs, peptides and ribozyme genetic effectors.
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Retrovirus Life Cycles
