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A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
07:59

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

The development of multi-epitope vaccines: epitope identification, vaccine design and clinical evaluation

A Sette1, B Livingston, D McKinney

  • 1Epimmune Inc., 5820 Nancy Ridge Drive, San Diego, California 92121, U.S.A.

Biologicals : Journal of the International Association of Biological Standardization
|February 20, 2002
PubMed

We have developed efficient methods for epitope identification and vaccine design. Our process for epitope selection based on the combined use of motif analyses, binding assays and immunogenicity evaluations is described. We also describe how the projected population coverage and vaccine design can be optimized. Finally, it is discussed how vaccine potency is evaluated by immunogenicity and antigenicity assays.

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