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Updated: Aug 4, 2026

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
Combined innominate artery reconstruction and coronary artery bypass grafting
Insights
This study presents a successful one-stage surgical approach for patients with severe coronary artery disease and innominate artery occlusion, combining bypass grafting and coronary artery bypass grafting (CABG). The technique ensures cerebral perfusion, leading to positive outcomes and demonstrating feasibility.
Area of Science:
- Cardiovascular Surgery
- Neurological Surgery
- Vascular Surgery
Background:
- Significant coronary artery disease often coexists with cerebrovascular disease.
- Innominate artery near-total occlusion poses a risk for neurological deficits like syncope or stroke.
- Protecting both the myocardium and cerebrum during cardiac surgery is critical.
Observation:
- Two patients with severe coronary artery disease and innominate artery occlusion experienced neurological symptoms.
- Both patients underwent a successful one-stage surgical reconstruction.
- The procedure involved aorto-carotid-subclavian bypass and coronary artery bypass grafting (CABG).
Findings:
- Cerebral perfusion was maintained via the reconstructed carotid bypass graft during cardiac arrest and hypothermia.
- Follow-up angiography showed extensive improvement in previously hypoperfused cerebral hemispheres.
- Patients were free from cerebral deficits and coronary angina post-surgery.
Implications:
- Combining innominate artery reconstruction with coronary artery surgery is a feasible and effective strategy.
- This surgical approach offers acceptable mortality and morbidity rates.
- Maintaining cerebral perfusion during cardiac arrest is key to successful outcomes in complex cardiovascular procedures.
Abstract:
Two patients having significant coronary artery disease with innominate artery near-total occlusion presented neurological deficit of syncope events or cerebellar and brain stem infarct. Both of them were successfully treated with one-stage reconstruction combined with aorto-carotid-subclavian bypass and coronary artery bypass grafting (CABG). While it could not be over-emphasized how to protect both myocardium and cerebrum during CABG, cerebral perfusion through the reconstructed carotid bypass graft is the key maneuver during cardiac arrest and moderate hypothermia. Hypoperfused cerebral hemispheres were both improved extensively in the follow-up angiography. The absence of cerebral deficit and the free from coronary angina suggested that surgical technique to combine innominate with coronary artery surgery is feasible with acceptable mortality and morbidity rate.
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