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Abdominal wall defects in Denmark, 1970-89.

M Bugge1, N V Holm

  • 1Wilhelm Johannsen Centre for Functional Genome Research, Department of Medical Genetics, Institute of Biochemistry and Genetics, University of Copenhagen, Denmark. MB@IMBG.ku.dk

Paediatric and Perinatal Epidemiology
|February 22, 2002
PubMed
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Gastroschisis rates increased significantly in recent decades, while omphalocele rates remained stable. This study analyzed abdominal wall defects in 469 infants from 20 birth cohorts (1970-1989).

Area of Science:

  • Pediatric Surgery
  • Congenital Abnormalities
  • Epidemiology

Background:

  • Increasing global incidence of gastroschisis reported over the past 20-30 years.
  • Omphalocele incidence has not shown similar upward trends.
  • Abdominal wall defects require accurate epidemiological data for understanding causes and outcomes.

Purpose of the Study:

  • To analyze trends in the prevalence of gastroschisis and omphalocele.
  • To investigate changes in the occurrence of abdominal wall defects over time.
  • To provide updated epidemiological data on these congenital anomalies.

Main Methods:

  • Utilized data from three nationwide registries, encompassing 20 birth cohorts from 1970-1989.
  • Included 469 infants with abdominal wall defects, reclassified into gastroschisis, omphalocele, and gross abdominal wall defects.

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  • Estimated registry completeness at 95% for livebirths and 90% for stillbirths.

    • Main Results:

    • Average point prevalence for gastroschisis was 1.33 per 10,000 live and stillbirths.
    • Gastroschisis prevalence showed fluctuations with no significant linear trend over the study period.
    • Average point prevalence for omphalocele was 2.07 per 10,000, with no significant change observed.

    Conclusions:

    • While gastroschisis rates fluctuated, no overall significant linear increase was detected across the entire study period.
    • Omphalocele prevalence remained stable, contrasting with reported increases in gastroschisis.
    • Geographical distribution of both conditions showed no county-specific differences.