Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neural plate patterning by secreted signals.

Oliver Wessely1, E M De Robertis

  • 1Howard Hughes Medical Institute, Department of Biological Chemistry, University of California, Los Angeles, CA 90095, USA.

Neuron
|February 22, 2002
PubMed
Summary

The discovery of Tiarin reveals a new signaling pathway crucial for central nervous system (CNS) development. This molecule, secreted by the nonneural ectoderm, adds to known signaling pathways like Sonic Hedgehog and Wnts.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of APOL1-Associated Pregnancy Complications on Kidney Disease Phenotypes in a HIV-Associated Nephropathy Mouse Model.

Kidney360·2026
Same author

A new brake on podocyte injury: ATOH8 meets TGF-β.

American journal of physiology. Renal physiology·2026
Same author

Inflammatory Stromal Aging in Ulcerative Colitis and Colitis-Associated Cancer.

bioRxiv : the preprint server for biology·2026
Same author

A single cell atlas of mouse podocytes upon injury identifies kidney zone-dependent responses.

bioRxiv : the preprint server for biology·2026
Same author

SPATIALLY PATTERNED PODOCYTE STATE TRANSITIONS COORDINATE AGING OF THE GLOMERULUS.

bioRxiv : the preprint server for biology·2026
Same author

Injury-induced paracrine effects on the podocyte's transcriptome.

American journal of physiology. Renal physiology·2026

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Signaling

Background:

  • Central nervous system (CNS) patterning involves complex interactions of signaling molecules like Sonic Hedgehog, Wnts, and BMPs.
  • Antagonists such as Chordin and Noggin also play critical roles in regulating these developmental pathways.

Discussion:

  • The identification of Tiarin, a novel secreted molecule, introduces a new signaling pathway into CNS development.
  • Tiarin is produced by the nonneural ectoderm at the boundary of the anterior and lateral neural plate.

Key Insights:

  • Tiarin represents a previously unrecognized component of the molecular machinery governing CNS development.
  • Its specific expression domain suggests a role in regional patterning of the neural tube.

Outlook:

  • Further research into Tiarin's downstream targets and interaction partners will elucidate its precise function.
  • Understanding this novel pathway could offer new therapeutic targets for neurological disorders.

Related Experiment Videos