[Formulation of lithium carbonate tablets with various binding substances]

Area of Science:

• Pharmaceutical Technology
• Materials Science

Background:

• Lithium carbonate is a crucial mood-stabilizing medication.
• Optimizing tablet formulations is essential for consistent drug efficacy and patient safety.

Purpose of the Study:

• To evaluate the impact of different binding agents on the physicochemical properties of lithium carbonate tablets.
• To identify the optimal formulation for enhanced tablet performance.

Main Methods:

• Tablets were prepared using various binders: maize starch, gelatin, sodium carboxymethylcellulose, and Kollidon 30.
• Evaluated parameters included lithium carbonate content, weight variation, hardness, friability, disintegration time, and dissolution rate.

Main Results:

• Tablets formulated with maize starch paste and internal starch addition exhibited the best overall properties.
• Specific improvements were noted in tablet integrity and drug release characteristics.

Conclusions:

• Maize starch paste, with internal starch, is an effective binder for lithium carbonate tablets.
• Formulation optimization significantly enhances the quality and performance of pharmaceutical dosage forms.