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[Formulation of calcium carbonate tablets with various binding substances]
E Gazikalović1, D Obrenović, Z Nidzović
1Vojnomedicinska akademija, Institut za farmaciju, Beograd.
Vojnosanitetski Pregled
|March 1, 1996
Summary
Calcium carbonate tablets were tested using various binders, including starch, microcrystal cellulose, gelatin, and sodium carboxymethylcellulose. Tablets formulated with starch exhibited superior properties, indicating its effectiveness as a binding agent in tablet manufacturing.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Context:
- Investigating the impact of diverse binding agents on tablet characteristics.
- Evaluating the physical and chemical properties of calcium carbonate tablets.
Purpose:
- To determine the optimal binding substance for calcium carbonate tablets.
- To compare the efficacy of microcrystal cellulose, gelatin, sodium carboxymethylcellulose, and starch as binders.
Summary:
- Calcium carbonate tablets were prepared using four different binding substances: microcrystal cellulose, gelatin, sodium carboxymethylcellulose, and starch.
- Key tablet properties assessed included calcium carbonate content, hardness, disintegration time, and dissolution rate.
- Tablets formulated with starch demonstrated the most favorable characteristics compared to other binders.
Impact:
- Identifies starch as a highly effective binder for calcium carbonate tablet formulations.
- Provides valuable data for optimizing tablet manufacturing processes and enhancing drug delivery.
- Contributes to the selection of appropriate excipients for improved tablet quality and performance.