Related Experiment Videos
Substituted 2-(R)-methyl piperazines as muscarinic M(2) selective ligands
Joseph A Kozlowski1, Guowei Zhou, Jayaram R Tagat
1Schering-Plough Research Institute, Kenilworth, NJ 07033-0539, USA. joseph.kozlowski@spcorp.com
Bioorganic & Medicinal Chemistry Letters
|February 23, 2002
Abstract:
A novel series of 2-(R)-methyl-substituted piperazines (e.g., 2) is described. They are potent M(2) selective ligands that have >100-fold selectivity versus the M(1) receptor. In the rat microdialysis assay, compound 14 showed significantly enchanced levels of acetylcholine after oral administration.