Related Experiment Video
Updated: Oct 2, 2026

Regenerative Peripheral Nerve Interface: Surgical Protocol for a Randomized Controlled Trial in Postamputation Pain
Published on: March 15, 2024
Lower limb amputations: registration of all lower limb amputations performed at the University Hospital of Trondheim,
1Department of Orthopaedic Surgery, University Hospital, Trondheim, Norway. ewitsoe@online.no
Insights
Lower limb amputations are 25 times more common in diabetic individuals. This study highlights the significant impact of diabetes mellitus and peripheral vascular disease on amputation rates and reamputation incidence.
Area of Science:
- Orthopedic Surgery
- Vascular Surgery
- Diabetology
Background:
- Lower limb amputations are a serious complication, particularly for patients with diabetes mellitus and peripheral vascular disease.
- Understanding the incidence and reamputation rates is crucial for improving patient outcomes.
Purpose of the Study:
- To analyze the incidence and types of primary lower limb amputations.
- To determine reamputation rates based on underlying diagnoses (diabetes, peripheral vascular disease).
- To compare amputation incidence in diabetic versus non-diabetic populations.
Main Methods:
- Retrospective analysis of all primary lower limb amputations at the University Hospital of Trondheim (1994-1997).
- Data collection included amputation level, patient demographics, and primary diagnosis.
- Calculation of incidence rates and reamputation rates.
Main Results:
- A total of 215 primary lower limb amputations were recorded.
- Diabetes mellitus (34%) and peripheral vascular disease (53%) were the leading causes.
- Reamputation rates were 19% for diabetic and 20% for peripheral vascular disease patients.
- The annual incidence of amputations was 25 times higher in diabetic subjects compared to non-diabetic subjects.
Conclusions:
- Diabetes mellitus and peripheral vascular disease are major drivers of lower limb amputations.
- Trans-tibial and knee disarticulations showed similar reamputation rates.
- Diabetic individuals face a significantly elevated risk of lower limb amputation.
Abstract:
The authors consecutively recorded all lower limb amputations performed at the University Hospital of Trondheim from January 1st, 1994 to January 1st, 1997. A total of 215 primary lower limb amputations were carried out in the study period: 40 partial foot amputations, 2 ankle disarticulations, 51 trans-tibial amputations, 68 knee disarticulations, 50 transfemoral amputations and 4 hip disarticulations. Seventy-four (74) (34%) of the amputees had diabetes mellitus, 113 (53%) had peripheral vascular disease and 28 (13%) of the amputees had various diagnoses. In those who were amputated due to diabetic and peripheral vascular disease the overall reamputation rate was 19% and 20%, respectively. The rates of reamputation at the trans-tibial and knee level were similar. In the city of Trondheim the annual incidence of primary amputations was 34 per 100,000 and 4.4 per 1,000 diabetic subjects. The incidence of lower limb amputations was 25 times higher in diabetic subjects compared to non-diabetic subjects.

