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[The relationship between angiotensin converting enzyme gene polymorphism and risk factors for coronary heart
1Department of Cardiology, 2nd Affilliated Hospital, Medical College, Zhejiang University, Hangzhou 310009, China.
Insights
The angiotensin converting enzyme (ACE) DD genotype may be an independent risk factor for coronary heart disease (CHD) in Chinese populations, despite no correlation with traditional CHD risk factors.
Area of Science:
- Cardiovascular Genetics
- Molecular Epidemiology
- Human Genetics
Background:
- Coronary heart disease (CHD) poses a significant global health burden.
- Genetic factors, including angiotensin converting enzyme (ACE) gene polymorphism, are implicated in CHD development.
- Understanding the interplay between ACE gene variants and traditional risk factors is crucial for risk stratification.
Purpose of the Study:
- To investigate the association between ACE gene polymorphism and established risk factors for coronary heart disease (CHD).
- To determine if ACE gene variants influence susceptibility to CHD independently of common risk factors.
Main Methods:
- A case-control study involving 148 CHD patients and 159 healthy controls.
- Polymerase chain reaction (PCR) was used for ACE genotyping.
- Standard questionnaires, physical examinations, and blood tests assessed CHD risk factors.
Main Results:
- No significant differences in traditional CHD risk factors (e.g., BMI, blood pressure, lipids, smoking, diabetes) were observed across different ACE genotypes.
- However, the DD genotype frequency was significantly higher in specific low-risk CHD subgroups compared to controls.
- This suggests a potential independent role of the DD genotype in CHD development.
Conclusions:
- ACE gene polymorphism is not associated with classical CHD risk factors in the studied population.
- The ACE DD genotype emerges as a potential independent risk factor for CHD in the Chinese population.
- Further research is warranted to elucidate the precise mechanisms underlying this association.
Objective:
To explore the relationship between angiotensin converting enzyme (ACE) gene polymorphism and risk factors for coronary heart disease (CHD).
Methods:
148 patients with CHD and 159 unrelated healthy individuals were studied using polymerase chain reaction (PCR) and genetic methods. Risk factors of CHD were assessed by standard questionnaire, physical examination and blood tests.
Results:
(1) There were no significant differences among genotypes in terms of years, sex, body mass index (BMI), systolic blood pressure, diastolic blood pressure, total cholesterol (TC), triglyceride (TG), low-density lipoprotein-cholesterol (LDL), high-density lipoprotein-cholesterol (HDL), HDL(2), HDL(3), apolipoprotein (Apo) AI, ApoB, and lipoprotein (a) [Lp (a)]. The prevalence rates of hyperlipidemia, hypertension (HT), cigarette smoking, diabetes mellitus (DM) and obesity were similar in the ACE genotypes (P > 0.05). (2) The DD genotype frequencies in low CHD risk groups, as defined by ApoB < 125 mg/dl and BMI
Conclusion:
There was no correlations between ACE gene polymorphism and the classic CHD risk factors noticed. ACE DD genotype seemed to be an independent risk factor for CHD in the Chinese population.