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Related Experiment Videos

Objective screening methods for prior refractive surgery in donor tissue.

Paula J Ousley1, Mark A Terry

  • 1Lions Vision Research Laboratory of Oregon, Portland, Oregon 97210, U.S.A.

Cornea
|February 28, 2002
PubMed
Summary

Screening donor corneas for prior laser refractive surgery is crucial. Pachymetry and curvature maps can help identify altered corneal thickness and shape, improving donor tissue suitability.

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Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Ophthalmic Diagnostics

Background:

  • Laser refractive surgery is increasing, impacting the corneal donor pool.
  • Current screening methods lack objectivity for detecting prior refractive surgery in donor corneas.

Purpose of the Study:

  • To evaluate the effectiveness of pachymetry and curvature maps in screening donor corneas for previous refractive surgery.
  • To establish objective criteria for identifying compromised donor tissue.

Main Methods:

  • Generated pachymetry and curvature maps using Orbscan for 40 normal donor eyes.
  • Defined normal ranges for central-to-midperipheral pachymetry and central-to-peripheral curvature differences.
  • Compared results from 10 donor eyes with prior refractive surgery against established normal ranges.

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Main Results:

  • Normal eyes showed an average midperipheral-central pachymetry difference of 0.040 ± 0.026 mm.
  • Four of 10 post-refractive surgery corneas fell outside the normal pachymetry range.
  • Normal eyes exhibited a 7-mm zone to 3-mm zone curvature difference of -0.2 ± 1.0 diopters.
  • Four (40%) post-refractive surgery corneas were identified by curvature analysis.
  • Combined pachymetry and curvature methods detected seven (70%) of the 10 post-refractive surgery corneas.

Conclusions:

  • Regional variations in corneal thickness and curvature can serve as indicators for prior myopic refractive surgery.
  • Further refinement of mathematical analysis may enhance the sensitivity of these screening techniques.
  • Objective screening methods are needed to ensure the quality of donor corneas.