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[Preformulation study of atenolol-containing solutions.. I. The pH dependence of thermostability]
1Semmelweis Egyetem Budapest, Gyógyszerészeti Intézet 1092 Budapest, Hógyes E. u. 7.
Acta Pharmaceutica Hungarica
|February 28, 2002
Abstract:
The stability of atenolol solutions was evaluated under accelerated isothermal degradation conditions at 90 degrees C. A specific and sensitive HPLC method was adapted to study the pH dependence of the stability. The maximum stability of atenolol was achieved at pH 4 with a k value of 1.1 x 10(-3) h-1. The degradation of atenolol followed first-order kinetics at above mentioned conditions.