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Antidiarrhoeal activity of Strychnos potatorum seed extract in rats
Swati Biswas1, T Murugesan, Sanghamitra Sinha
1Department of Pharmaceutical Technology, Faculty of Engineering & Technology, Jadavpur University, Calcutta 700 032, India.
Abstract:
The antidiarrhoeal activity of the methanol extract of the dried seeds of Strychnos potatorum (MESP) has been evaluated out in rats using different models (castor oil-induced diarrhoea, effects on gastrointestinal motility and on PGE(2)-induced gastric enteropooling. MESP (100, 200 and 400 mg/kg, p.o.) significantly (P<0.001) inhibited the frequency of defaecation and reduced the wetness of faecal droppings in castor oil-induced diarrhoea, decreased the propulsion of charcoal meal through the gastrointestinal tract, and also reduced the PGE(2)-induced enteropooling.