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Infection and nitric oxide.

John B Hibbs1

  • 1Division of Infectious Diseases, Department of Medicine, University of Utah School of Medicine, and VA Medical Center, Salt Lake City, Utah 84132, USA. john.hibbs@hsc.utah.edu

The Journal of Infectious Diseases
|February 28, 2002
PubMed
Summary
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Discover how cytokine-activated macrophages synthesize nitric oxide from L-arginine. This research explains key components of nitric oxide synthase isoforms, crucial for innate immunity and cell-mediated defense mechanisms.

Area of Science:

  • Immunology
  • Biochemistry
  • Cell Biology

Background:

  • The author's fellowship in infectious diseases at Stanford University (1969-1971) under Jack Remington shaped his research trajectory.
  • Early work focused on understanding the mechanisms behind an in vitro cytotoxicity assay developed during the fellowship.

Observation:

  • Investigations aimed to elucidate the mechanistic basis of a specific in vitro cytotoxicity assay.
  • The research explored the biochemical pathways involved in macrophage activation and cytotoxic function.

Findings:

  • The study led to the 1987 discovery of nitric oxide (NO) synthesis from L-arginine by cytokine-activated macrophages.
  • Identified key components (precursor, products, inhibitor) for the enzymatic synthesis of NO, relevant to all three nitric oxide synthase (NOS) isoforms.

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Implications:

  • This work elucidated the biochemical basis of cytokine-induced NO synthesis.
  • Highlights the significance of NO in innate resistance and cell-mediated immune responses.
  • Provides foundational knowledge for understanding immune cell function and inflammatory processes.