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Related Experiment Videos

Clinical experience with verapamil.

J Vohra, D Hunt, G Sloman

    The Medical Journal of Australia
    |September 13, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Intravenous verapamil effectively restored sinus rhythm for supraventricular tachycardia and controlled heart rate in atrial fibrillation. This antiarrhythmic drug demonstrated safety with minimal side effects.

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    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Supraventricular tachycardia and atrial fibrillation are common arrhythmias.
    • Effective antiarrhythmic agents are crucial for managing cardiac rhythm disorders.

    Purpose of the Study:

    • To evaluate the efficacy and safety of intravenous verapamil in treating supraventricular tachycardia and atrial fibrillation.
    • To assess the electrophysiological effects of verapamil on cardiac conduction.

    Main Methods:

    • Verapamil was administered intravenously to patients with supraventricular tachycardia and atrial fibrillation.
    • Intracardiac conduction studies using His bundle electrograms were performed.
    • Adverse events were monitored and recorded.

    Main Results:

    Related Experiment Videos

  • Verapamil restored sinus rhythm in 33 of 40 supraventricular tachycardia episodes.
  • The drug effectively reduced ventricular rate in atrial fibrillation.
  • Prolongation of atrioventricular nodal conduction was observed in 8/9 cases; distal conduction remained unaffected.
  • Bradycardia and hypotension occurred in two patients but responded to atropine.

    • Conclusions:

    • Intravenous verapamil is an effective antiarrhythmic agent for supraventricular tachycardia and atrial fibrillation.
    • Verapamil demonstrates a favorable safety profile with generally mild side effects.