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Related Experiment Videos

Perinatal programming, renal development, and adult renal function.

Julie R Ingelfinger1, Lori L Woods

  • 1Division of Pediatric Nephrology, Massachusetts General Hospital, Boston 02114, USA. jingelfinger@partners.org

American Journal of Hypertension
|February 28, 2002
PubMed
Summary

Maternal diet and perinatal events influence lifelong health, impacting organ development and disease susceptibility. This concept, known as perinatal programming, links fetal origins of adult disease (FOAD) to later health outcomes.

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Area of Science:

  • Developmental biology
  • Epidemiology
  • Nutritional science

Background:

  • Maternal diet and perinatal events impact organ development and adult health.
  • The concept of perinatal programming, or fetal origins of adult disease (FOAD), emerged from observations linking birth weight to adult cardiovascular disease and hypertension.
  • Epidemiological studies suggest a strong connection between early-life conditions and later-life health issues.

Purpose of the Study:

  • To review evidence supporting the concept of perinatal programming.
  • To explore how maternal nutrition and perinatal factors influence organogenesis and long-term health.
  • To examine findings from experimental animal models investigating these effects.

Main Methods:

  • Review of epidemiological studies, including those by Barker et al.

Related Experiment Videos

  • Analysis of experimental animal model studies.
  • Nutritional and pharmacological manipulation in animal models to study programming effects.

    • Main Results:

    • Gestational diet and perinatal events significantly affect organ development and function.
    • Lower birth weight is inversely associated with cardiovascular disease and hypertension in adulthood.
    • Animal studies corroborate epidemiological findings, demonstrating programming effects through dietary and pharmacological interventions.

    Conclusions:

    • Perinatal programming is a critical determinant of adult disease susceptibility.
    • Maternal environment plays a crucial role in shaping an individual's lifelong health trajectory.
    • Further research using experimental models can elucidate mechanisms underlying the fetal origins of adult disease.