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The effect of high dose and short interval HBV vaccination in individuals with chronic hepatitis C

Ramazan Idilman1, Maria Nicola De, Alessandra Colantoni

  • 1Department of Medicine, Loyola University Medical Center, Maywood, Illinois, USA.

The American Journal of Gastroenterology
|February 28, 2002
PubMed

Insights

High-dose, short-interval hepatitis B virus (HBV) vaccination is safe and effective for individuals with chronic hepatitis C (HCV). This vaccination schedule can elicit an early antibody response, improving protection against HBV in this vulnerable population.

Area of Science:

  • Hepatology
  • Immunology
  • Vaccinology

Background:

  • Standard hepatitis B virus (HBV) vaccination efficacy is reduced in individuals with chronic hepatitis C (HCV).
  • Assessing alternative vaccination schedules is crucial for improving HBV protection in HCV patients.

Purpose of the Study:

  • To evaluate the response rate to a high-dose, short-interval HBV vaccination in individuals with chronic hepatitis C.
  • To determine the safety and immunogenicity of this enhanced vaccination schedule.

Main Methods:

  • 152 individuals with chronic hepatitis C received 40 microg of HBV vaccine monthly for 3 months.
  • A control group of 26 healthy individuals received the same schedule.
  • Non-responders received an 80 microg booster dose.

Main Results:

  • 72% of chronic hepatitis C patients seroconverted, compared to 92% in controls.
  • Effective immunity (>100 mIU/ml) showed no significant difference between groups (51% vs 54%).
  • Response rates were lower in cirrhotics (54%) than non-cirrhotics (80%), but improved after a booster dose (74% vs 88%). No major adverse effects were observed.

Conclusions:

  • A high-dose, short-interval HBV vaccination schedule is safe for individuals with chronic hepatitis C.
  • This schedule can induce an effective and early antibody response, enhancing HBV protection in this population.
Abstract

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