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The synthesis and biological characterization of a ceramide library
Young-Tae Chang1, Jaehwa Choi, Sheng Ding
1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, San Diego, California 92037, USA.
Journal of the American Chemical Society
|February 28, 2002
Abstract:
A facile synthesis of a combinatorial ceramide library and their activities in the NF-kappaB pathway and in apoptosis induction/prevention were demonstrated. A novel NF-kappaB activating molecule was discovered among ceramide containing beta-galactose, and the structural requirements of ceramides for apoptosis induction was elucidated.
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