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Related Experiment Videos

Frontal lobe dysfunction in amyotrophic lateral sclerosis.

I Evdokimidis1, T S Constantinidis, P Gourtzelidis

  • 1ENG Lab of Neurology Clinic of Athens Medical School, Aeginitio Hospital, Vas. Sofias 72-74, 11528, Athens, Greece. ievdokim@cc.uoa.gr

Journal of the Neurological Sciences
|February 28, 2002
PubMed
Summary
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Frontal lobe dysfunction is present in one-third of amyotrophic lateral sclerosis (ALS) patients, indicated by ocular motor tasks and neuropsychological tests. This dysfunction correlates with speech impairment, not eye movement accuracy.

Area of Science:

  • Neuroscience
  • Neurology

Background:

  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease.
  • Frontal lobe dysfunction can manifest in various neurological conditions.

Purpose of the Study:

  • To investigate frontal lobe dysfunction in ALS patients.
  • To utilize ocular motor paradigms and neuropsychological testing to assess cognitive function in ALS.

Main Methods:

  • Fifty-one ALS patients performed ocular motor tasks (three-choice and remembered saccade).
  • Patients underwent clinical and neuropsychological evaluations, including Wisconsin and Stroop tests.
  • Distractibility factors (DF) were assessed in the three-choice task.

Main Results:

  • One-third of ALS patients showed signs of frontal dysfunction.

Related Experiment Videos

  • ALS patients exhibited increased eye movement latencies in the remembered saccade task.
  • Frontal dysfunction, particularly high DF, correlated with the severity of dysarthria.

    • Conclusions:

    • Frontal lobe dysfunction is a notable feature in a subset of ALS patients.
    • Ocular motor tasks, especially those measuring distractibility, can reveal cognitive deficits in ALS.
    • The findings suggest a link between frontal lobe dysfunction and speech impairment in ALS.