Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Respiratory failure.

Janice L Zimmerman1

  • 1Baylor College of Medicine, Houston, TX 77030, USA. janicez@bcm.tmc.edu

Blood Purification
|February 28, 2002
PubMed
Summary
This summary is machine-generated.

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) cause hypoxemic respiratory failure. Lower tidal volume mechanical ventilation reduces mortality, while further research is needed for optimal ALI/ARDS therapies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gender equality and equity in intensive care: an international Delphi consensus study.

Intensive care medicine·2026
Same author

Executive Summary: Society of Critical Care Medicine Guidelines for the Allocation of Critical Care Resources to Adults During Crisis-Level Shortages.

Critical care medicine·2026
Same author

Society of Critical Care Medicine Guidelines for the Allocation of Critical Care Resources to Adults During Crisis-Level Shortages.

Critical care medicine·2026
Same author

Critical Care Management of Patients After Cardiac Arrest: A Scientific Statement from the American Heart Association and Neurocritical Care Society.

Neurocritical care·2023
Same author

Critical Care Management of Patients After Cardiac Arrest: A Scientific Statement From the American Heart Association and Neurocritical Care Society.

Circulation·2023
Same author

Poisons and Patients.

Critical care clinics·2021
Same journal

Could serum CA125 aid the clinical assessment of volume status of end-stage kidney disease patients treated by peritoneal dialysis patients?

Blood purification·2026
Same journal

From Bench to Bedside: Implications and Interventions for Endotoxin Exposure in Lipopolysaccharide-Induced Apoptosis and Eryptosis.

Blood purification·2026
Same journal

Feasibility Study of a Smartphone App and Web Portal for Remote Monitoring of Chronic Kidney Disease and Peritoneal Dialysis populations: A mixed-method study.

Blood purification·2026
Same journal

Treatment of Focal Segmental Glomerulosclerosis in Low- and Middle-Income Countries: Emerging Extracorporeal Therapies.

Blood purification·2026
Same journal

Creatinine Paradox in CRRT: Higher Levels, Lower Mortality - A MIMIC-IV Validation Study.

Blood purification·2026
Same journal

Expanded Home Hemodialysis trial (HHDx): Study Design and Baseline Characteristics of a Pragmatic Real-World Cohort.

Blood purification·2026
See all related articles

Area of Science:

  • Pulmonary Medicine
  • Critical Care Medicine
  • Pathophysiology

Background:

  • Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are leading causes of hypoxemic respiratory failure.
  • Pathophysiology involves direct/indirect lung injury with exudative, fibroproliferative, and recovery phases, driven by inflammation.
  • Current understanding highlights inflammation's central role in ALI/ARDS.

Purpose of the Study:

  • To review current understanding and interventions for ALI/ARDS.
  • To identify therapeutic strategies that reduce mortality in ALI/ARDS patients.

Main Methods:

  • Review of existing literature on ALI/ARDS pathophysiology and treatments.
  • Analysis of clinical trial outcomes for interventions like mechanical ventilation, fluid management, inhaled nitric oxide, and glucocorticoids.

Related Experiment Videos

Main Results:

  • Mechanical ventilation using lower tidal volumes (< or = 30 cm H2O plateau pressure) reduces mortality.
  • Inhaled nitric oxide has not shown outcome benefits despite improving oxygenation.
  • Glucocorticoids may benefit the fibroproliferative phase by reducing chronic inflammation.

Conclusions:

  • Optimizing mechanical ventilation strategies is crucial for reducing ALI/ARDS mortality.
  • Further rigorous clinical trials are essential to establish effective therapies for ALI/ARDS.
  • Investigating fluid management and the role of glucocorticoids warrants continued research.