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Tuberculosis transmitted through transplantation.

J C Graham1, A M Kearns, J G Magee

  • 1Microbiology Department, Freeman Hospital, High Heaton, UK. j.c.graham@ncl.ac.uk

The Journal of Infection
|March 1, 2002
PubMed
Summary
This summary is machine-generated.

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Tuberculosis in organ transplant recipients is serious and often occurs outside the lungs. This study highlights a rare instance of donor-transmitted tuberculosis in two transplant patients.

Area of Science:

  • Transplantation Medicine
  • Infectious Diseases
  • Microbiology

Background:

  • Tuberculosis (TB) presents significant risks for solid organ transplant (SOT) recipients, often leading to severe illness and death.
  • Extra-pulmonary TB is a common manifestation in this patient population.
  • While TB reactivation is the typical cause, donor transmission is a rare but critical consideration.

Observation:

  • Two cases of probable donor-transmitted Mycobacterium tuberculosis infection were identified in SOT recipients.
  • Both patients presented with extra-pulmonary tuberculosis.
  • The Mycobacterium tuberculosis isolates from both patients were indistinguishable.

Findings:

  • Hemi-nested inverse PCR targeting the IS 6110 region confirmed the genetic identity of the Mycobacterium tuberculosis isolates.

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  • This genetic similarity strongly supports transmission from a common source, likely the organ donor.
  • This finding underscores the potential for donor-mediated infectious disease transmission in transplantation.

    • Implications:

    • Highlights the importance of donor screening for infectious diseases, including tuberculosis.
    • Suggests that molecular methods like IS 6110 PCR can be crucial in identifying transmission events.
    • Emphasizes the need for vigilance regarding rare but severe complications in solid organ transplantation.