Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatoimmunology: a perspective.

Ian R Mackay1

  • 1Department of Biochemistry and MolecularBiology, Monash University, Clayton, Victoria, Australia. ian.mackay@med.monash.edu.au

Immunology and Cell Biology
|March 1, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In drug-induced, immune-mediated hepatitis, interleukin-33 reduces hepatitis and improves survival independently and as a consequence of FoxP3+ T-cell activity.

Cellular & molecular immunology·2018
Same author

Evolving Trends in Female to Male Incidence and Male Mortality of Primary Biliary Cholangitis.

Scientific reports·2016
Same author

Changing nomenclature for PBC: From 'cirrhosis' to 'cholangitis'.

Clinics and research in hepatology and gastroenterology·2015
Same author

Changing nomenclature for PBC: From 'cirrhosis' to 'cholangitis'.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2015
Same author

Changing Nomenclature for PBC: From 'Cirrhosis' to 'Cholangitis'.

The American journal of gastroenterology·2015
Same author

Changing Nomenclature for PBC: From 'Cirrhosis' to 'Cholangitis'.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2015
Same journal

Multi-Omics Comes of Age: Immune Profiling of Human Aging.

Immunology and cell biology·2026
Same journal

Mechanisms of Therapeutic Resistance and Recent Advances in Glioblastoma Treatment.

Immunology and cell biology·2026
Same journal

Ancestry Matters in Decoding Immunity.

Immunology and cell biology·2026
Same journal

Improving COVID-19 Vaccine Uptake Among Ethnic Minority Communities in Wales: A Community-Based Approach.

Immunology and cell biology·2026
Same journal

4-1BB Expression and Signaling Regulates MAIT Cell Activation and Effector Functions.

Immunology and cell biology·2026
Same journal

Highlights of 2025: Advances in the T-Cell Regulation of Germinal Center Response.

Immunology and cell biology·2026
See all related articles

The liver, a unique lymphoid organ, defends against microbes, induces tolerance, and disposes of lymphocytes. Immune responses in the liver can be triggered by viruses, autoimmune conditions, or drug-induced neoantigens.

Area of Science:

  • Immunology
  • Hepatology
  • Gastroenterology

Background:

  • The liver possesses unique immunological properties, functioning as a lymphoid organ.
  • These properties are crucial for innate defense, immune tolerance, and lymphocyte homeostasis.
  • Dysregulation of these properties underlies various liver pathologies.

Purpose of the Study:

  • To review recent advances in understanding the immunopathogenesis of liver diseases.
  • To highlight the liver's role as a key immunological site.
  • To explore the mechanisms behind viral, autoimmune, and drug-induced liver conditions.

Main Methods:

  • Review of current literature on hepatoimmunology.
  • Analysis of immune responses in viral hepatitis (Hepatitis B and C).

Related Experiment Videos

  • Examination of autoimmune hepatitis and primary biliary cirrhosis pathogenesis.
  • Investigation of drug-induced neoantigen responses.

    • Main Results:

    • Hepatotropic viruses (Hepatitis B, C) can evade immune elimination, leading to chronic infection.
    • Autoimmune responses target hepatocytes (autoimmune hepatitis) or biliary ductules (primary biliary cirrhosis).
    • Drug metabolism can generate neoantigens, triggering adverse immune reactions.

    Conclusions:

    • Hepatoimmunology is a critical subspecialty for understanding liver diseases.
    • Immune dysregulation in the liver contributes to significant pathologies.
    • Advances in immunopathogenesis pave the way for targeted therapies.