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Updated: Oct 2, 2026
Sectioning Mammary Gland Whole Mounts for Lesion Identification
Published on: July 24, 2017
[Histological grading in ductal carcinoma in situ of the breast]
1Department of Pathology, Cancer Hospital, Shanghai Medical University, Shanghai 200032.
Objective:
To study the significance of histological grading as a prognostic factor in ductal carcinoma in situ of the breast.
Methods:
According to Van Nuy's classification, 32 cases of ductal carcinoma in situ (DCIS) of the breast were divided into three grades.
Results:
Low grade (well differentiated, low grade DCIS) 12 patients (37.5%); Intermediate grade, 9 patients (28.1%); High grade (poorly differentiated DCIS) 11 patients (34.4%). Among the high grade DCIS, the histological subtypes were comedo (9 patients), micto papillary (1 patient) and solid (1 patient). The positive expression of c-erbB-2, p53 and MIB-1 in high grade DCIS was higher than that in intermediate and low grade DCIS. The difference between high grade and low grade DCIS was significant (P < 0.05). The expression of ER in high grade DCIS was lower than that in intermediate and low grade DCIS.
Conclusions:
Histological grading of breast ductal carcinoma in situ may be a good prognostic factor.
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