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Related Experiment Videos

Pentoxifylline for treating venous leg ulcers.

A B Jull1, J Waters, B Arroll

  • 1Nursing Service, Auckland Hospital, Private Bag 92024, Auckland, New Zealand. andrewj@adhb.govt.nz

The Cochrane Database of Systematic Reviews
|March 1, 2002
PubMed
Summary

Pentoxifylline aids venous leg ulcer healing, proving more effective than placebo, especially with compression therapy. While generally safe, gastrointestinal side effects were more common.

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Area of Science:

  • Vascular Medicine
  • Dermatology
  • Pharmacology

Background:

  • Compression bandaging improves venous leg ulcer healing.
  • Some ulcers remain unhealed, and some patients cannot use compression therapy.
  • Pentoxifylline, a hemorheologic agent, has been used for venous leg ulcers without prior systematic review.

Purpose of the Study:

  • To systematically review the efficacy of pentoxifylline for treating venous leg ulcers.
  • To compare pentoxifylline with placebo or other therapies.
  • To assess its use with or without compression therapy.

Main Methods:

  • Searched specialized databases (Cochrane), reference lists, journals, and contacted experts.
  • Included randomized trials comparing pentoxifylline to placebo or other treatments.

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  • Extracted and verified data from nine trials involving 572 adults.

    • Main Results:

    • Pentoxifylline significantly improved ulcer healing compared to placebo (RR 1.41).
    • Pentoxifylline combined with compression was more effective than placebo with compression (RR 1.30).
    • Adverse effects, primarily gastrointestinal, were more frequent but not statistically significant.

    Conclusions:

    • Pentoxifylline is an effective adjunct to compression for venous leg ulcers.
    • Evidence suggests potential efficacy without compression, but requires cautious interpretation.
    • Gastrointestinal disturbances are the most common adverse effects.