Related Experiment Videos
Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d
Atsushi Mizoguchi1, Emiko Mizoguchi, Hidetoshi Takedatsu
1Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA. amizoguchi@partners.org
Abstract:
B cells possess a variety of immune functions that are involved in normal and abnormal immune responses, including autoimmune disorders. Through murine models of intestinal inflammation, we here demonstrate a B cell subset that is induced in gut-associated lymphoid tissues and is characterized by CD1d upregulation. This B cell subset appears under a chronic inflammatory environment, produces IL-10, and suppresses progression of intestinal inflammation by downregulating inflammatory cascades associated with IL-1 upregulation and STAT3 activation rather than by altering polarized T helper responses. This study indicates that B cells, by producing cytokines such as IL-10, can act as regulatory cells in immunologically mediated inflammatory reactions.