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MUC5AC, CEACAM7, and DUOX2 Distinguish Colitis-associated Cancer from Sporadic Colorectal Cancer
Tetsushi Kinugasa1,2, Taichi Matsumoto3, Toshiyuki Okada4
1Fukuoka Mirai Hospital, Fukuoka, Japan; tetsushi-kinugasa@lta-med.or.jp.
Anticancer Research
|July 29, 2026
Summary
Researchers identified three genes, MUC5AC, CEACAM7, and DUOX2, with distinct expression patterns in colitis-associated colorectal cancer (CAC) compared to sporadic colorectal cancer (CRC). These genes may aid in differentiating between these cancer types.
Area of Science:
- Gastroenterology
- Oncology
- Molecular Biology
Background:
- Ulcerative colitis (UC) increases the risk of colitis-associated colorectal cancer (CAC).
- CAC carcinogenesis is distinct from sporadic colorectal cancer (CRC).
- Limited molecular markers exist to differentiate CAC from CRC.
Purpose of the Study:
- Identify genes preferentially expressed in CAC.
- Evaluate the diagnostic relevance of these genes for differentiating CAC from CRC.
Main Methods:
- RNA sequencing of normal, inflamed, and cancer tissues from UC patients with CAC.
- Comparison with tissue from a patient with sporadic CRC.
- Validation of candidate genes using immunohistochemistry.
Main Results:
- Three genes (MUC5AC, CEACAM7, DUOX2) showed higher expression in CAC than in sporadic CRC.
- Immunohistochemistry confirmed protein expression of these markers in CAC tissues.
- CEACAM7 and MUC5AC showed lower expression in sporadic CRC.
Conclusions:
- MUC5AC, CEACAM7, and DUOX2 have distinct expression profiles in CAC versus sporadic CRC.
- Combined evaluation of these markers may aid in differential diagnosis between CAC and CRC.
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