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Antigen-dependent B-cell development

Annaiah Cariappa1, Shiv Pillai

  • 1Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA.

Current Opinion in Immunology
|March 1, 2002
PubMed

There is growing evidence that the development of naïve B cells depends on the interaction of self antigens with the BCR. A view that has emerged over the past year is that BCR signal output contributes in a large part to the developmental fate of peripheral B cells. Differences in antigen-receptor signal strength may determine whether B cells assume a marginal zone, follicular or B-1 phenotype.

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