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Hyalinizing clear cell carcinoma of minor salivary gland: case report
Madhavan Manoharan1, Nor Hayati Othman, Abdul Rani Samsudin
1Department of Pathology, Hospital Universiti Sains Malaysia (HUSM), Kubang Kerian, Kelantan, Malaysia. madhavan@kb.usm.my
Abstract:
Hyalinizing clear cell carcinoma is a low-grade neoplasm of the minor salivary gland composed exclusively of epithelial cells and not myoepithelial cells. It predominantly affects the oral cavity of adult females. It is microscopically characterized by hyalinizing stroma and clear cells, which are typically positive for cytokeratin markers and negative for S 100 and smooth muscle actin (SMA). Cystic degeneration can also be present. Pathologists should be aware of this new entity so as not to misdiagnose otherwise. To our knowledge, this is the first case report of its kind from Malaysia.