[Neuroimmunoendocrine interactions: their role in dysregulatory pathologies]

The author reviews the trends in development of views of interaction of the basic regulating systems (nervous, endocrine and immune) supporting control and adaptive functions of the brain. Two historical periods are singled out: the period of neuroendocrinology and neuroimmunoendocrinology. Mechanisms of interaction of brain regulating systems and various autoimmune diseases resulting from defects in the above mechanisms are considered. Development of cooperative interactions of the above regulating systems at early evolutionary stages is suggested.