Related Experiment Video
Updated: Aug 19, 2026

Culturing Primary Rat Inner Medullary Collecting Duct Cells
Published on: June 21, 2013
Antidiuretic hormone-V2-receptor-aquaporin-2 system in rat kidneys during acute inflammation
A V Misharin1, A B Resnenko, O V Fidelina
1Research Center of Endocrinology, Russian Academy of Medical Sciences, Moscow, Russia. aml@mail.ru
Abstract:
Expression of antidiuretic hormone V(2)-receptor, water channel protein aquaporin-2, and cytokines interleukin-1b and interleukin-6 was studied in the kidneys of rats with acute inflammation produced by intraperitoneal injection of lipopolysaccharide in a dose of 250 microg/100 g. Reduced expression of aquaporin-2 and V(2)-receptor led to impairment of concentration capacity in the kidneys and decrease in urine osmolarity.
Related Concept Videos
Physiology of the Genitourinary System III: Urine Concentration and Dilution
Hormonal Regulation
Regulation of Water Output
Diabetes Insipidus II: Pathophysiology
Regulation of Water Intake
Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion

