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Updated: Oct 2, 2026
High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages
Published on: August 11, 2014
[Comparative study of the effectiveness of HBcAg presentation to the immune system using attenuated Salmonella
L I Karpenko1, T A Veremeĭko, G M Ignat'ev
1State Research Center of Virology and Biotechnology Vector-Research Institute of Bioengineering, Closed Joint-Stock Company Vector-Best, Koltsovo, Novosibirsk Region, Russia.
Abstract:
In this work the results of obtaining HBcAg-producing attenuated Salmonella strains, serovars S. enteritidis and S. typhimurium, and their comparative study is presented. As revealed in this study, attenuated S. enteritidis strain E-23 and S. typhimurium strain T-10, producing HBcAg, induce cell-mediated and humoral immune response to HBcAg after injected into anovals. After injection S. typhimurium strain T-10 induces a much higher titer of specific antibodies than S. enteritidis strain E-23. The level of specific antibodies induced by recombinant HBcAg seems to correlate with the capacity of salmonellae for survival inside macroorganisms.
