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[Thrombogenesis in patients with ischemic stroke].

J Iłzecka1, Z Stelmasiak, B Dobosz

  • 1Katedra i Klinika Neurologii Akademii Medycznej w Lublinie. jeannei@kki.net.pl

Neurologia I Neurochirurgia Polska
|March 5, 2002
PubMed
Summary

Thrombin-antithrombin III complexes (TAT) were significantly elevated in ischemic stroke patients compared to controls. Higher TAT levels correlated with stroke severity and extent, indicating increased thrombin generation in these patients.

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Area of Science:

  • Biochemistry
  • Neurology
  • Hematology

Background:

  • Thrombinogenesis is a key process in blood coagulation.
  • Thrombin-antithrombin III complexes (TAT) are markers of thrombin activity.
  • Ischemic stroke involves complex pathophysiological mechanisms, including coagulation.

Purpose of the Study:

  • To evaluate thrombin-antithrombin III (TAT) complex levels in patients with ischemic stroke.
  • To correlate TAT levels with stroke severity, extent, and presence of atrial fibrillation.

Main Methods:

  • Blood samples were collected from 25 ischemic stroke patients and 15 controls.
  • TAT complexes were quantified using enzyme-linked immunosorbent assay (ELISA) on days 1, 5, and 12 post-stroke.
  • Patients were categorized by stroke extent, severity, and presence of atrial fibrillation.

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Main Results:

  • TAT complexes were significantly higher in ischemic stroke patients versus controls.
  • Elevated TAT levels were observed in patients with larger stroke extent and more severe strokes.
  • Higher TAT levels were noted in stroke patients with atrial fibrillation on day 1 compared to those without.

Conclusions:

  • Ischemic stroke is associated with intense thrombinogenesis.
  • TAT complex levels can serve as a biomarker for stroke severity and activity.
  • Coagulation activation is a significant component of ischemic stroke pathophysiology.