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Related Experiment Videos

Grape seed extract activates Th1 cells in vitro.

Narayanan Nair1, Supriya Mahajan, Ram Chawda

  • 1Division of Allergy, Immunology, and Rheumatology, Department of Medicine, State University of New York at Buffalo and Kaleida Health, 14203, USA.

Clinical and Diagnostic Laboratory Immunology
|March 5, 2002
PubMed
Summary

Grape seed extract (GSE) boosts antiviral and antitumor immunity by increasing gamma interferon (IFN-gamma) production. This study shows GSE enhances immune cell responses, potentially through IFN-gamma induction.

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Area of Science:

  • Immunology
  • Molecular Biology
  • Phytochemistry

Background:

  • Flavonoids possess diverse biological activities, including antitumor and antiviral effects.
  • The precise molecular mechanisms behind these effects remain largely unknown.
  • Grape seed extract (GSE) is rich in procyanidin flavonoids.

Purpose of the Study:

  • To investigate the hypothesis that GSE's flavonoid constituents induce gamma interferon (IFN-gamma) production.
  • To explore the potential of GSE as an immunostimulant via Th1 cytokine induction.

Main Methods:

  • Peripheral blood mononuclear cells (PBMCs) from healthy donors were treated with GSE.
  • Reverse transcription-polymerase chain reaction (RT-PCR) was used to quantify IFN-gamma mRNA.
  • Intracytoplasmic IFN-gamma and secreted IFN-gamma levels were measured.

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Main Results:

  • GSE significantly induced the transcription of IFN-gamma mRNA.
  • GSE did not affect the transcription of the Th2 cytokine, interleukin-6 (IL-6).
  • A concurrent increase in intracellular and secreted IFN-gamma was observed.

Conclusions:

  • GSE demonstrates a significant immunostimulatory effect.
  • The beneficial effects of GSE may be attributed to its ability to induce IFN-gamma.
  • This induction of IFN-gamma by GSE highlights its potential in modulating immune responses.