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Cytoskeleton of apicomplexan parasites
Naomi S Morrissette1, L David Sibley
1Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. naomi@borcim.wustl.edu
Microbiology and Molecular Biology Reviews : MMBR
|March 5, 2002
Summary
Apicomplexa parasites, including malaria-causing Plasmodium, possess unique cytoskeletal structures. This review details their actin, myosin, microtubules, and novel intermediate filaments, crucial for parasite functions.
Area of Science:
- Parasitology
- Cell Biology
- Molecular Biology
Background:
- Apicomplexa are obligate intracellular parasites responsible for significant human and agricultural diseases.
- Key examples include Plasmodium (malaria), Toxoplasma (toxoplasmosis), Cryptosporidium, Eimeria, and Theileria.
- These parasites exhibit conserved yet unique cellular structures and processes.
Purpose of the Study:
- To review the current understanding of the Apicomplexa cytoskeleton.
- To explore the properties of cytoskeletal proteins and their roles in parasite biology.
- To highlight novel cytoskeletal elements discovered in these parasites.
Main Methods:
- Literature review of existing research on Apicomplexa cytoskeleton.
- Analysis of published data on cytoskeletal protein properties and functions.
- Synthesis of information regarding motility, invasion, and replication mechanisms.
Main Results:
- Apicomplexa possess unusual actin and myosin proteins.
- Microtubule organization is highly stereotyped across different apicomplexan species.
- Novel intermediate filament-like structures have been identified.
Conclusions:
- The Apicomplexa cytoskeleton is a complex and dynamic structure essential for parasite survival.
- Understanding these elements offers potential targets for antiparasitic interventions.
- Further research into novel cytoskeletal components may reveal new therapeutic strategies.
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