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[Hereditary persistence of alpha-fetoprotein: report of a case]
1Service de radiothérapie et d'oncologie médicale, hôpital Notre Dame de Bon-Secours, CHR de Metz-Thionville, 1, place Philippe-de-Vigneulles, BP 81065, 57038 Metz, France. cplatini@wanadoo.fr
Introduction:
Hereditary persistence of alpha-fetoprotein is a rare disorder which exists with no simultaneous disease. The tenth case in the world (two brothers with seminoma and their father) is documented and a complete literature review was done.
Exegesis:
It is transmitted as an autosomal dominant; a disease point mutation has been identified. The failure to recognize hereditary persistence of alpha-fetoprotein sometimes involves unjustified treatments.
Conclusion:
The occurrence of this situation is probably underestimated and it could explain residual levels of alpha-fetoprotein.