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Identification of a New HLA-DRB5 Allele in a Chinese Han Individual, HLA-DRB5*01:01:17

Liumei He1, Zhanrou Quan1, Hongyan Zou1

  • 1Immunogenetics Laboratory, Shenzhen Institution of Transfusion Medicine, Shenzhen Blood Center, Shenzhen, China.

HLA
|September 18, 2026
PubMed

Keywords:
HLA‐DRB5*01:01:17new allelenext generation sequencing (NGS)

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Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...