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Updated: Sep 19, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

Molecular Identification of HLA-DPB1*1651:01: A Novel Allele Discovered by Sequence Comparison of HLA-DPB1 Exon 2

Zhan-Rou Quan1, Jie Liu1, Bing-Na Yang1

  • 1Shenzhen Blood Center, Shenzhen Institute of Transfusion Medicine, Shenzhen, Guangdong, China.

HLA
|September 17, 2026
PubMed

Keywords:
DPB1*1651:01NGSmutation

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Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...