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[Cause Analysis of HLA-B Allele Missed Detection Based on AlltypeTM FastplexTM Next Generation Sequencing]
Zhan-Rou Quan1, Bing-Na Yang1, Jie Liu1
1Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen 518040, Guangdong Province, China.
Next-generation sequencing (NGS) using amplicon-based methods can miss human leukocyte antigen (HLA) alleles, particularly in homozygous cases. Verification with multiple techniques is crucial for accurate HLA genotyping.
Area of Science:
- Immunogenetics
- Molecular Biology
- Genomic Medicine
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