Characterisation of the Novel HLA-DPB1*1763:01 Allele by Next-Generation Sequencing
Jie Liu1, Zhan-Rou Quan1, Bing-Na Yang1
1Shenzhen Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen, Guangdong, China.
HLA
|July 31, 2025
Summary
A novel Human Leukocyte Antigen (HLA) variant, HLA-DPB1*1763:01, has been identified. This variant is distinguished from HLA-DPB1*02:01:64 by a single nucleotide substitution at codon-14 in exon 1.
Area of Science:
- Immunogenetics
- Molecular biology
Background:
- The Human Leukocyte Antigen (HLA) system plays a critical role in immune response.
- Genetic variations within HLA genes contribute to diverse immune profiles and disease susceptibility.
Purpose of the Study:
- To characterize a newly identified HLA-DPB1 allele.
- To detail the specific genetic differences between the novel and a known HLA-DPB1 allele.
Main Methods:
- Sequence analysis of the HLA-DPB1 gene.
- Comparison of nucleotide sequences between different HLA-DPB1 alleles.
Main Results:
- A novel HLA-DPB1 allele, designated HLA-DPB1*1763:01, was identified.
- This new allele differs from HLA-DPB1*02:01:64 by a single nucleotide substitution.
- The substitution occurs at codon-14 within exon 1 of the HLA-DPB1 gene.
Conclusions:
- The identification of HLA-DPB1*1763:01 expands the known HLA allele repertoire.
- Understanding these specific genetic variations is crucial for high-resolution HLA typing and immunological studies.
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