Extended Characterisation of the Coding Sequence of the HLA-C*07:101 Allele by Third-Generation Sequencing
Romain Ferru-Clément1, Perrine Augustin1, Pierre Brossard1
1Laboratoire d'Histocompatibilité et Immunogénétique, Etablissement Français du Sang Nouvelle Aquitaine, Poitiers, France.
HLA
|August 13, 2026
Summary
A novel Human Leukocyte Antigen C (HLA-C) allele, HLA-C*07:101, has been identified. It differs from a known allele, HLA-C*07:04:01:01, by a single nucleotide substitution.
Area of Science:
- Immunogenetics
- Molecular Biology
Background:
- Human Leukocyte Antigen (HLA) genes are crucial for immune response.
- Allelic variations within HLA genes can impact immune system function and disease susceptibility.
Purpose of the Study:
- To characterize a newly identified HLA-C allele.
- To describe the specific genetic difference between this new allele and a known one.
Main Methods:
- DNA sequencing
- Bioinformatic analysis of genetic variations.
Main Results:
- A novel HLA-C allele, designated HLA-C*07:101, was identified.
- This allele differs from HLA-C*07:04:01:01 by a single nucleotide substitution at codon 35 in exon 2.
Conclusions:
- The discovery of HLA-C*07:101 expands the known HLA-C allele repertoire.
- This specific nucleotide substitution may have implications for immune recognition or function.
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