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Published on: September 6, 2017
The HLA-C*08:01:45 Allele, Identified by Next-Generation Sequencing in an Indian Individual
Samir Agarwal1, Shikha Kumari1, Neha Bairagi1
1Department of Lab Science and Molecular Medicine, Army Hospital Research and Referral, New Delhi, India.
HLA
|August 10, 2026
Summary
A new Human Leukocyte Antigen (HLA) allele, HLA-C*08:01:45, has been identified. It differs from a known allele by a single nucleotide change in the second exon.
Area of Science:
- Immunogenetics
- Molecular biology
- Human leukocyte antigen (HLA) system
Background:
- The Human Leukocyte Antigen (HLA) system plays a critical role in immune response and transplantation.
- Accurate HLA allele identification is crucial for matching donors and recipients and understanding immune system function.
Purpose of the Study:
- To report the discovery and characterization of a novel HLA allele, HLA-C*08:01:45.
- To detail the specific genetic variation distinguishing this new allele from previously known ones.
Main Methods:
- Sequence analysis of the HLA-C gene.
- Comparison of the novel allele sequence with existing HLA allele databases.
- Identification of single nucleotide polymorphisms (SNPs) and their locations.
Main Results:
- A new HLA allele, designated HLA-C*08:01:45, was identified.
- This allele is distinguished from HLA-C*08:01:01:01 by a single synonymous substitution (c.111C>A) located in exon 2.
- The substitution does not alter the amino acid sequence of the HLA protein.
Conclusions:
- The identification of HLA-C*08:01:45 expands the known diversity of HLA-C alleles.
- This finding contributes to the comprehensive cataloging of HLA genetic variations, important for immunogenetic research and clinical applications.
