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Related Experiment Videos

Propranolol, 14C-morphine accumulation and avoidance: peripheral and central variables.

W C Black, W J McBride, H J Grosz

    Pharmacology, Biochemistry, and Behavior
    |July 1, 1975
    PubMed
    Summary

    Pretreatment with propranolol significantly reduced morphine levels in the brain and blood. However, propranolol still lessened morphine

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    Area of Science:

    • Neuropharmacology
    • Behavioral Pharmacology

    Background:

    • Propranolol pretreatment attenuates morphine's behavioral effects.
    • This attenuation was previously hypothesized to be due to reduced morphine levels.

    Purpose of the Study:

    • To investigate whether propranolol's attenuation of morphine's anti-avoidance effects is solely due to reduced central morphine concentrations.

    Main Methods:

    • Rats were pretreated with propranolol intraperitoneally.
    • Labeled morphine was administered IP, and its levels were measured in various brain regions and plasma.
    • Morphine was also administered intraventricularly after propranolol pretreatment in rats performing a free-operant avoidance task.

    Main Results:

    • Propranolol pretreatment substantially reduced 14C-morphine levels in blood plasma and multiple brain regions (neostriatum, pons-medulla, midbrain, cerebral cortex, cerebellum).

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  • Despite direct central administration of morphine (intraventricularly), propranolol pretreatment still attenuated the anti-avoidance effects of morphine.

    • Conclusions:

    • Reduced central morphine levels do not solely explain the attenuation of morphine's behavioral effects by propranolol.
    • Propranolol may influence morphine's action through mechanisms other than altering its central nervous system concentration.