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Platelet function during pregnancy: an evaluation using the PFA-100 analyser.

A Vincelot1, N Nathan, D Collet

  • 1Department of Anaesthesia and Intensive Care, Service d'Hématologie, CHU Dupuytren, Limoges, France.

British Journal of Anaesthesia
|March 7, 2002
PubMed
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This study found that platelet function, measured by the PFA-100 analyser, may be impaired in pregnant women with thrombocytopenia or pre-eclampsia. Platelet function was preserved in some cases of pregnancy-induced thrombocytopenia even with low platelet counts.

Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Clinical Pathology

Background:

  • Clinical assessment of platelet function in pregnancy primarily relies on bleeding time and platelet count, which have limitations.
  • The Platelet Function Analyzer-100 (PFA-100) offers an in vitro method for assessing platelet function.
  • Understanding platelet function in pregnant women with conditions like thrombocytopenia and pre-eclampsia is crucial for clinical management.

Purpose of the Study:

  • To investigate the correlation between platelet number and platelet function using the PFA-100 in pregnant women.
  • To evaluate platelet function in normal pregnancy, thrombocytopenia of pregnancy, and pre-eclampsia with or without thrombocytopenia.

Main Methods:

  • A prospective study evaluated platelet function in 4 groups of pregnant women using the PFA-100 with collagen and epinephrine (PFA-EPI) or ADP (PFA-ADP) agonists.

Related Experiment Videos

  • Thrombocytopenia was defined as a platelet count < 150 G/L.
  • Statistical analysis included the Mann-Whitney U-test and correlation analysis.

    • Main Results:

    • PFA-EPI was significantly increased in pregnant women with thrombocytopenia (Group II), pre-eclampsia (Group III), and pre-eclampsia with thrombocytopenia (Group IV) compared to normal pregnancy (Group I).
    • PFA-ADP was significantly increased only in Group II compared to normal pregnancy.
    • A correlation between PFA-ADP results and platelet count was observed exclusively in Group IV (pre-eclampsia with thrombocytopenia).

    Conclusions:

    • Increased PFA values and the correlation between PFA-ADP and platelet count in hypertensive thrombocytopenic women suggest decreased platelet function in these patients.
    • Platelet function may be preserved in pregnancy-induced thrombocytopenia even at platelet counts as low as 60 G/L.
    • The PFA-100 may provide valuable insights into platelet dysfunction in specific obstetric conditions.