Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in lymphocytic cluster distribution during extracorporeal immunoadsorption.

Jana-Maria Schneidewind-Müller1, Roland E Winkler, Michael Tiess

  • 1Dialysis-Group North, Rostock, Germany.

Artificial Organs
|March 7, 2002
PubMed
Summary

Protein A immunoadsorption may modulate the immune system, potentially improving autoimmune diseases. This apheresis treatment showed distinct immune cell changes in patients achieving remission.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The German Lipoprotein Apheresis Registry-Summary of the ninth annual report.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·2022
Same author

Adsorptive cytapheresis for ulcerative colitis with focus on removing platelets and platelet-aggregates.

Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·2022
Same author

Using the World Apheresis Association Registry Helps to Improve the Treatment Quality of Therapeutic Apheresis.

Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie·2021
Same author

Novel Leucocyte/Thrombocyte Apheresis for Induction of Steroid-Free Remission in Ulcerative Colitis: A Controlled Randomized Pilot Study.

Journal of Crohn's & colitis·2019
Same author

Granulocyte/monocyte adsorptive apheresis for the treatment of therapy-refractory chronic active ulcerative colitis.

Scandinavian journal of gastroenterology·2018
Same author

Rationale and design of MultiSELECt: A European Multicenter Study on the Effect of Lipoprotein(a) Elimination by lipoprotein apheresis on Cardiovascular outcomes.

Atherosclerosis. Supplements·2017

Area of Science:

  • Immunology
  • Nephrology
  • Neurology
  • Rheumatology

Background:

  • Apheresis treatment success is typically measured by antibody reduction and disease scores.
  • Disease severity does not always correlate with antibody levels, indicating complex disease mechanisms.

Purpose of the Study:

  • To investigate the immunological effects of protein A immunoadsorption in patients with various autoimmune and alloimmune conditions.
  • To explore potential correlations between immune cell changes and clinical outcomes following apheresis.

Main Methods:

  • Analyzed lymphocyte subpopulations (T cells, B cells, NK cells) and inflammatory proteins in 15 patients undergoing protein A immunoadsorption over 8 years.
  • Categorized patients into immediate-responding (remission) and delayed-responding (chronic treatment) groups based on clinical outcomes.

Related Experiment Videos

Main Results:

  • Patients achieving remission (Group 1) exhibited a significant increase in activated T and cytolytic T cells.
  • A concurrent decrease in B cells was observed in Group 1 patients, correlating with clinical improvement.
  • Inflammatory protein levels were also analyzed, though specific correlations with outcomes require further study.

Conclusions:

  • Protein A immunoadsorption may induce immunomodulation, characterized by specific T and B cell dynamics.
  • The observed immune changes suggest a potential mechanism for clinical remission in certain autoimmune and alloimmune diseases.
  • Further immunological research is warranted to confirm these immunomodulatory effects and their clinical implications.