[Combination hypotensive therapy in patients with essential hypertension]

In men and women with moderately severe essential hypertension (EH), efficiency has been analyzed of different schemes of combined hypotensive drug therapy depending on the hemodynamic type of circulation with taking account of basic indices for the 24-hour profile of arterial pressure (AP). It is shown that the baseline indices for a long-term AP monitoring (1-3 days) determine the choice of individualized differentiated therapy consisting of a combination of two (atenolol and enalapril maleate) or three (atenolol, enalapril maleate, hydrochlorothiazide) hypotensive drug preparations. Individual schemes of the above drug therapy permitted not only the correction of identified disturbances in the 24-hour AP profile but also contributed to the improvement of hemodynamic maintenance of graded physical loads, favouring positive changes in the structural-and-functional status of the myocardium, which facts suggest indirectly an improvement of prognosis in EH patients.