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Autonomic functions in Buerger's disease.

K Singh1, S Sood

  • 1Department of Physiology, Pt. B. D. Sharma, Postgraduate, Institute of Medical Sciences (PGIMS), Rohtak-124 001.

Indian Journal of Physiology and Pharmacology
|March 9, 2002
PubMed
Summary

This study found that patients with Buerger's disease (thromboangiitis obliterans) exhibit reduced sympathetic nervous system reactivity. These findings suggest autonomic dysfunction contributes to the vasospastic phenomena characteristic of this condition.

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Area of Science:

  • Cardiovascular Physiology
  • Autonomic Nervous System Function
  • Vascular Disease Pathophysiology

Background:

  • Buerger's disease (thromboangiitis obliterans - TAO) is characterized by vasospastic phenomena.
  • Autonomic nervous system (ANS) dysfunction may play a role in TAO pathophysiology.

Purpose of the Study:

  • To evaluate autonomic reactivity in patients diagnosed with Buerger's disease.
  • To compare autonomic responses between Buerger's disease patients and healthy controls.

Main Methods:

  • Autonomic function tests were performed on 12 Buerger's disease patients and age/sex-matched non-smoking controls.
  • Tests included basal heart rate and blood pressure, Valsalva maneuver, 30:15 ratio, head-up tilt (HUT), and cold pressure test (CPT).

Main Results:

  • Buerger's disease patients showed a significantly higher basal heart rate (P < 0.001) without blood pressure variation compared to controls.
  • Increased Valsalva ratio (P < 0.01) and 30:15 ratio (P < 0.001) were observed in TAO patients.
  • Significant blood pressure fall during HUT (P < 0.001) and reduced systolic blood pressure during CPT (P < 0.01) were noted in TAO patients.

Conclusions:

  • Autonomic reactivity testing indicates lower sympathetic reactivity in Buerger's disease patients.
  • These findings support the hypothesis that autonomic dysfunction contributes to the vasospastic nature of Buerger's disease.

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