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Related Experiment Videos

Wound strength in a clinical material.

A Nachemson, A Nordwall

    Scandinavian Journal of Plastic and Reconstructive Surgery
    |January 1, 1975
    PubMed
    Summary

    Human wound strength after surgery is comparable to animal models. This study found no significant difference in breaking strength between polyglycolic acid (Dexon) and synthetic polyamid (Supramid) sutures in 56 scoliosis patients.

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    Area of Science:

    • Biomedical Engineering
    • Surgical Research
    • Wound Healing Studies

    Background:

    • Previous wound strength research primarily used animal or laboratory tissues, lacking direct human comparisons.
    • Understanding human wound healing and tensile strength is crucial for surgical outcomes.

    Purpose of the Study:

    • To compare the breaking strength of human surgical wounds sutured with polyglycolic acid (Dexon) and synthetic polyamid (Supramid).
    • To assess the relevance of animal models for human wound healing studies.

    Main Methods:

    • Investigated breaking strength in 56 patients undergoing two-stage scoliosis surgery.
    • Measured wound thickness and length (wound area) to determine breaking strength.
    • Compared two suture materials: polyglycolic acid (Dexon) and synthetic polyamid (Supramid).

    Main Results:

    • The breaking strength of 14-day-old wounds was approximately 57 N/cm² wound area.
    • This value is comparable to findings from animal wound healing experiments (e.g., rats, rabbits).
    • No significant difference in wound strength was observed between the two suture materials used.

    Conclusions:

    • Animal models for wound healing research appear relevant for human tissue studies.
    • Both polyglycolic acid (Dexon) and synthetic polyamid (Supramid) sutures provide comparable wound strength in this patient cohort.
    • Surgical wounds in scoliosis patients healed uneventfully regardless of the suture material used.

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